Fig. 1: Overview of approach.
From: Genetic determinants of monocyte splicing are enriched for disease susceptibility loci
Paired gene and transcript QTL mapping, using paired-end RNA-seq of primary monocytes that had been incubated in an untreated state or following exposure to IFN-γ or LPS. Imputed genotypes were derived from array-based genotyping. g/t/mQTL mapping was performed using QTLtools with biological significance and potential implications for disease inferred via integration with GWAS trait-associated SNPs. All data is available via a web browser.
