Fig. 4: Interaction between DNA methylation and expression.
From: Genetic determinants of monocyte splicing are enriched for disease susceptibility loci
a The number and proportion of g/tQTLs that are associated with mSNPs in naïve and LPS-stimulated monocytes (posterior probabilities of PPH4 > 0.8, FDR < 1 × 10−6). b A Steiger directionality test was conducted to determine the direction of causality between DNA methylation and gene/transcript expression. Our results indicated that the causal direction was most likely opposite, suggesting that increases in expression were linked to reduced methylation. This finding is in line with the hypothesis that hypermethylation decreases the expression level in most cases. The area of boxes in the mosaic plot is proportional in size to the number of observed counts. Abbreviations: “n” represents and lists the specific number of g/tQTL-mQTL pairs, CS‘Context Specific’.
