Fig. 7: Why does CLλTL outperform CLpATL?
From: Genetic controllers for enhancing the evolutionary longevity of synthetic gene circuits in bacteria
a Time-series output for representative optimal controllers with nB = 300 aa. (Open-loop black dotted line). b Protein output per cell pA over time for the first day of simulation according to mutation state, considering only states with a mutated process and a fully functional controller. c Protein output per cell pA over time for the first day of simulation, considering only states with a mutated controller and fully functional process (solid line mutation in ωB, dotted line mutation in ωC). d, e Growth rates λ according to mutation state. Main plots show time series over the first day. Horizontal lines indicate differences in the maximum growth rates of each state over the first day. d Only states with mutated process. e Only states with mutated controllers (solid line/square is mutation in ωB, dotted line/triangle is mutation in ωC). Simulation results are provided as a Source Data file.
