Fig. 4: Substrate scope for nucleophilic ring opening of ABB using aniline as nucleophile; installation of aza-azetidine in marketed drugs, bioactive molecules, and fatty acids. | Nature Communications

Fig. 4: Substrate scope for nucleophilic ring opening of ABB using aniline as nucleophile; installation of aza-azetidine in marketed drugs, bioactive molecules, and fatty acids.

From: HFIP-assisted Brønsted acid-catalyzed ring opening of 1-azabicyclo[1.1.0]butane to access diverse C3-quaternary aza-azetidines and indole-azetidines

Fig. 4

[a] Reaction condition: 2 (0.2 mmol), aniline (0.4 mmol), TFA (10 mol%), HFIP (0.2 mL), after removal of HFIP add Et3N (0.8 mmol), Boc2O (0.4 mmol), DCM (5 mL).

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