Table 4 Parameter estimates for co-amoxiclav minimum inhibitory concentration (MIC) genotype-phenotype model

From: Escherichia coli phylogeny drives co-amoxiclav resistance through variable expression of TEM-1 beta-lactamase

Variable

Beta coefficient posterior mean

95% HPD (l, u)

pMCMC

Intercept

3.92

2.92, 4.85

<1e-05

blaTEM-1 cell copy number

2.07

1.38, 2.78

<1e-05

blaTEM-1 genome copy number (>ā€‰1 vs. 1)

0.97

0.02, 1.90

0.0414

blaTEM-1 promoter SNV vs. wildtype

G175Aa

0.17

-0.35, 0.69

0.5313

C32Ta

6.06

4.15, 8.08

<1e-05

C32Ta and G175Aa

5.87

3.89, 7.87

<1e-05

ampC promoter SNV vs. wildtype

G-28Ab and C17Tb

0.44

āˆ’0.63, 1.48

0.4122

G-28Ab

0.87

āˆ’0.89, 2.58

0.3039

G-18Ab and C-1Tb

0.83

āˆ’1.37, 3.11

0.4402

  1. All values were taken from chain 1. For single-nucleotide variant (SNV) vs. wildtype, E. coli K12 was used as the wildtype baseline. Lower (l) and upper (u) values are given for the 95% highest posterior density (HPD) intervals. pMCMC is the posterior probability that the coefficient was positive (defined in the Supplementary Information).
  2. a Numbering by Sutcliffe26.
  3. b Numbering by Jaurin14.
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