Fig. 4: GlyR-loop occupies both binding sites within one GephE dimer simultaneously.
From: Gephyrin filaments represent the molecular basis of inhibitory postsynaptic densities
a Surface representation of GephE dimer in complex with GlyR-loop lowpass filtered to 6 Å (light blue) with highlighted density depicting the position of GlyR-loop (orange). b Surface representation of GephE dimer without GlyR-loop lowpass filtered to 6 Å. For further information, see Supplementary Fig. 10). c GephE dimer in complex with GlyR-loop modeled after structure prediction. GephE dimer is shown in surface presentation with highlighted GephE monomers (light gray, dark gray). GlyR-loop is shown in stick presentation with color-coded amino acid sequence. Amino acid sequence of modeled GlyR-loop with respective positions is depicted beneath. d Magnification of GlyR-loop binding site one occupied by the core binding motive of GlyR-loop (red). e Magnification of second GlyR-loop binding site occupied by the C-terminally extended binding motive of GlyR-loop (blue).
