Fig. 1: Ionizing radiation-induced tumour cells exhibit aberrant gene expression and pervasive accumulation of accessible chromatin sites. | Nature Communications

Fig. 1: Ionizing radiation-induced tumour cells exhibit aberrant gene expression and pervasive accumulation of accessible chromatin sites.

From: TP63 mediates the generation of tumour-specific chromatin loops that underlie MYC activation in radiation-induced tumorigenesis

Fig. 1

A Volcano plots showing genes that are up- and downregulated in BERP35T1 and BERP35T4 tumour cells compared to BEP2D cells. B Heatmap showing significantly enriched GO terms of up-regulated genes in BERP35T1 and BERP35T4 tumour cells. C Heatmaps showing the read intensities of 2-kb regions centered on ATAC-seq peaks in normal BEP2D cells and tumour cells. All ATAC-seq peaks were categorized into 3 types: gained in tumour cells, lost in tumour cells, and unchanged (from top to bottom). All replicates were shown in one heatmap with the same order of all genes. The pie charts show the proportions of ATAC-seq peaks located at gene promoters of each type of ATAC-seq peak (orange: ATAC-seq peaks at promoters, ATAC-seq peaks not at promoters).

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