Fig. 2: A/B compartments switching and alterations in intra-TAD structures are associated with dysregulated gene expression in the ionizing radiation-induced tumour cells.
A Pie charts showing the proportions of each type of locus (stable compartment A, A-to-B switching, B-to-A switching and stable compartment B) comparing BEP2D with BERP35T1 and BERP35T4 respectively. B Overlap of the compartments from B-to-A in BERP35T1 and BERP35T4. C Violin plots showing the log2 fold changes in the expression of genes located within each type of locus (A-to-B compartment switching, unchanged compartment, and B-to-A compartment switching). P-values from a two-sided t-test between groups are shown. Box limits represent 25th percentile, median and 75th percentile. Whiskers represent 5th and 95th percentile. Source data are provided as a Source Data file. D Boxplots showing the log2 fold changes in the expression of genes located within each type of TAD (from left to right: decreased SDOC in tumour, unchanged SDOC in tumour, increased SDOC in tumour). P-values from a two-sided t-test between groups are shown. Box limits represent 25th percentile, median and 75th percentile. Whiskers represent 5th and 95th percentile. Source data are provided as a Source Data file. E Stacked bar plots showing the fractions of the 3 groups of TADs in regions with an A-to-B compartment switching and regions with a B-to-A compartment switching. F Examples of A/B compartment switching with chromatin accessibility and gene expression tracks, where the shadings correspond to genomic regions with compartment switching that associates with alterations in chromatin accessibility and transcriptional activity.
