Fig. 3: Dynamic changes in different SDOC during the process of radiation-induced tumor formation.
A The contact frequency alterations within SDOC-decreased, SDOC-stable, and SDOC-increased TADs in BERP35T4 (left) and BERP35T1 (right) cells. Box limits represent 25th percentile, median and 75th percentile. Whiskers represent 5th and 95th percentile. Significance: n.s. not significant, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, two-sided t-test. Source data are provided as a Source Data file. B Boxplots showing the log2 fold changes in the expression of genes located at the 3 types of loci (contact-increased, contact-decreased and other) within the 3 groups of TADs (SDOC increased in tumour cells, SDOC unchanged in tumour cells and SDOC decreased in tumour cells). Box limits represent 25th percentile, median and 75th percentile. Whiskers represent 5th and 95th percentile. Significance: n.s. not significant, *P < 0.05, ***P < 0.001, two-sided t-test. Source data are provided as a Source Data file. C Boxplots showing the log2(FPKM + 1) in the expression of oncogenes located at the 3 groups of TADs (SDOC increased in tumour cells, SDOC unchanged in tumour cells and SDOC decreased in tumour cells). Box limits represent 25th percentile, median and 75th percentile. Whiskers represent 5th and 95th percentile. Significance: n.s. not significant, *P < 0.05, **P < 0.01, ***P < 0.001, two-sided t-test. Source data are provided as a Source Data file.
