Fig. 5: TP63 anchors multiple tumour-specific chromatin loops that instruct MYC oncogene activation in radiation-induced tumour cells. | Nature Communications

Fig. 5: TP63 anchors multiple tumour-specific chromatin loops that instruct MYC oncogene activation in radiation-induced tumour cells.

From: TP63 mediates the generation of tumour-specific chromatin loops that underlie MYC activation in radiation-induced tumorigenesis

Fig. 5

A Hi-C contact maps of the MYC locus in BEP2D, BERP35T1 and BERP35T4 cells. Differential contact maps between each type of tumour cells and normal BEP2D cells are shown below the Hi-C contact maps of the corresponding tumour types. The red arrows mark the locus where a new TAD boundary in each radiation-induced tumor cells was established. The green arrows mark the anchors of the tumour-specific hub of chromatin loops. B Expression level of MYC in BEP2D, BERP35T1 and BERP35T4 cells. C Genome-browser like plot of the MYC locus showing RefSeq genes, ATAC-seq, TP63, CTCF, Cohesin CUT&Tag tracks of BEP2DNC, BEP2DOE and BERP35T1 cell lines.

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