Fig. 5: Structural comparison of autoinhibitory states of MET1 and DNMT1. | Nature Communications

Fig. 5: Structural comparison of autoinhibitory states of MET1 and DNMT1.

From: Cryo-EM reveals evolutionarily conserved and distinct structural features of plant CG maintenance methyltransferase MET1

Fig. 5

a Structures of apo-MET1full (left) and apo-DNMT1 (right, PDB: 4WXX). N-lobe, C-lobe, connecting linker, and autoinhibitory/acidic-linkers are colored blue, orange, red, and green, respectively. b Overlay of apo-MET1full (yellow) with apo-DNMT1 (cyan, PDB: 4WXX). The RFTS2 and RFTS domains are colored salmon and purple, respectively. c Close-up views on the left are the C-lobe of the RFTS domain (light purple) and the autoinhibitory linker (green), and the right shows the MTase domain of DNMT1 (cyan). The residues involved in the interactions are displayed as blue sticks. d Close-up view of the N-lobe of the RFTS2 domain (salmon) and the MTase domain (light yellow) in MET1.

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