Fig. 2: CryoEM structures of NavAb-Nav1.7-7A9 Fab and CD20-RTX Fab complexes. | Nature Communications

Fig. 2: CryoEM structures of NavAb-Nav1.7-7A9 Fab and CD20-RTX Fab complexes.

From: Disulfide-constrained Fabs overcome target size limitation for high-resolution single particle cryoEM

Fig. 2

Composite cryoEM maps of NavAb-Nav1.7 complexes with A WT or B 4DS variants of the 7A9 Fab colored by local resolution. Dashed boxes indicate the constant domains of the Fabs. EM density for selected map regions illustrating improvements in resolution in the 7A9 HC (C, D) and LC (E, F) from the indicated structures. Composite cryoEM maps of CD20 complexes with G WT or H 4DS variants of the rituximab (RTX) Fab colored by local resolution. Dashed boxes indicate the constant domains of the Fabs. EM density for selected map regions illustrating improvements in resolution in the RTX HC (I, J)or LC (K, L) from the indicated structures.

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