Fig. 4: CryoEM structure of KRASG12C-GNE-1952-2H11.4DS Fab complex. | Nature Communications

Fig. 4: CryoEM structure of KRASG12C-GNE-1952-2H11.4DS Fab complex.

From: Disulfide-constrained Fabs overcome target size limitation for high-resolution single particle cryoEM

Fig. 4

A CryoEM map of KRASG12C-GNE-1952-2H11.4DS Fab complex at a resolution of 2.8 Å with KRASG12C in cyan, GNE-1952 in pink, GDP in green, 2H11.6DS HC in yellow, and LC in light gray. B Map of KRASG12C-GNE-1952-2H11.4DS complex colored by local resolution. C Locally refined cryoEM map of KRASG12C-GNE-1952-2H11.4DS complex colored by local resolution. EM density for the entire KRASG12C-GNE-1952-2H11.4DS complex (D), GNE-1952 covalently bound to C12 (E), GDP (F), and selected regions of KRASG12C (G, H) illustrating high resolution features.

Back to article page