Table 1 Demographic and clinical characteristics of the ABIDE1 and ABIDE2 cohorts

From: Local activity alterations in individuals with autism correlate with neurotransmitter properties and ketamine-induced brain changes

 

ABIDE11

ABIDE21

 
 

Autism

TD

p (Autism vs. TD)

Autism

TD

p (Autism vs. TD)

p (Autism vs. Autism from ABIDE 1 and 2)

n

405 (46.1)

473 (53.9)

 

395 (45.5)

474 (54.5)

  

age, years

17.3 ( ± 8.6)

17.3 ( ± 7.9)

0.9652

15.6 ( ± 9.8)

15.1 ( ± 9.3)

0.4572

0.0082

age range, years

7.0-64.0

6.5-56.2

 

5.1-62.0

5.9-64.0

  

sex, female

50 (12.3)

84 (17.8)

0.0263

53 (13.4)

140 (29.5)

<0.0013

0.6513

FIQ

108.5 ( ± 15.2)

108.7 ( ± 14.0)

0.8732

107.1 ( ± 15.7)

115.1 ( ± 12.6)

<0.0012

0.1842

maximal motion

       

- translation, mm

1.0 ( ± 0.6)

0.9 ( ± 0.6)

0.0412

0.9 ( ± 0.6)

0.9 ( ± 0.6)

0.3642

0.0832

- rotation, degree

0.9 ( ± 0.6)

0.9 ( ± 0.6)

0.1932

1.0 ( ± 0.7)

0.9 ( ± 0.6)

0.412

0.3142

ADOS

12.1 ( ± 4.1)

1.3 ( ± 1.4)

<0.0012

10.4 ( ± 3.6)

1.8 ( ± 1.7)

<0.0012

<0.0012

- communication

4.1 ( ± 2.5)

0.5 ( ± 0.7)

<0.0012

3.1 ( ± 1.4)

1.2 ( ± 1.1)

<0.0012

<0.0012

- RSI

8.2 ( ± 3.1)

0.8 ( ± 1.0)

<0.0012

7.1 ( ± 2.5)

0.6 ( ± 1.0)

<0.0012

<0.0012

- SBRI

2.3 ( ± 2.3)

0.1 ( ± 0.3)

<0.0012

1.6 ( ± 1.4)

0.1 ( ± 0.3)

<0.0012

<0.0012

  1. 1Numbers present either absolute numbers plus percent or mean plus standard deviation, 2t-test (two-tailed), 3χ2-test (two-tailed), TD typically developed controls, ABIDE Autism Brain Imaging Data Exchange, FIQ full scale IQ, ADOS Autism Diagnostic Observation Schedule, RSI reciprocal social interaction, SBRI stereotyped behaviors and restricted interests. maximal available clinical data for ABIDE-I ADOS (n = 300 with Autism), for ABIDE-II ADOS (n = 238 with Autism).
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