Fig. 4: IQ model homogenization over multiple trajectories.
From: IceQream: Quantitative chromosome accessibility analysis using physical TF models
A Comparison of sequence motifs for Hox and Mesp2 transcription factors before and after (bottom row) homogenization across three trajectories in the mouse gastrulation manifold. B Matrix showing the PSSM (Position-Specific Scoring Matrix) correlation between 63 motif models for individual trajectories (rows) and 25 homogenized models (columns). The rightmost columns indicate the trajectory of each model. C Model performance (R²) before (brown) and after (blue) homogenization for mouse gastrulation trajectories. The number above the bar indicates the number of motifs in each model. D CRE dynamics across the full mouse gastrulation manifold. Top heatmap shows the normalized ATAC signal for 70 variable CRE clusters (columns) across 369 metacells (rows), colored by their cell type (right annotation). The bottom heatmap shows the log2 enrichment of 61 full-manifold motifs in the CRE clusters. TF motifs are manually grouped into families of transcription factors (TFs).
