Fig. 1: Overview of the study design and analysis. | Nature Communications

Fig. 1: Overview of the study design and analysis.

From: Comparative single-cell and spatial profiling of anti-SSA-positive and anti-centromere-positive Sjögren’s disease reveals common and distinct immune activation and fibroblast-mediated inflammation

Fig. 1

a Clinical overview of Sjögren’s disease (SjD) and motivation for this study. The upper section illustrates common symptoms of SjD, and the lower section classifies patients based on autoantibody profiles (SSA+ and/or CENT+) by associated clinical features. The bottom part of the figure shows a schematic of the sample processing and analysis workflow, including biopsy collection from the salivary gland, followed by single-cell RNA sequencing (scRNA-seq) and T- and B-cell receptor repertoire analysis. Created in BioRender. Inamo, J. (2025) https://BioRender.com/pgjlzhs. b The UMAP plot illustrates broad cell types identified in the salivary glands. c Marker gene expressions in different cell types.

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