Fig. 6: Cell state switch induced by indisulam treatment can lead to upregulation of GD2 expression through epigenetic reprogramming. | Nature Communications

Fig. 6: Cell state switch induced by indisulam treatment can lead to upregulation of GD2 expression through epigenetic reprogramming.

From: RBM39 degrader invigorates innate immunity to eradicate neuroblastoma despite cancer cell plasticity

Fig. 6

a Cartoon depicts the GD2 synthesis and related key enzymes. Cer, ceramide, N-acylsphingosine; Glc, glucose; Gal, galactose; GalNac, N-acetylgalactosamine; Neu5Ac, N-acetyl neuraminic acid. b–e Expression of the two key enzymes in GD2 synthesis in 4 different neuroblastoma models. P values are calculated by two-sided, Student t-test when biological replicates n = 3. f, g Snapshots of H3K27Ac CUT&Tag and ATAC-seq at B4GALNT1 and ST8SIA1 genomic loci using the IGV program, displaying the peaks in naïve vs resistant SK-N-AS cells. h Flow cytometry analysis of GD2 expression in naïve and indisulam-resistant SK-N-AS cells. Left, isotype IgG as control; right, anti-GD2 intensities. The experiment was done once. Source data are provided as a Source Data file.

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