Fig. 3: The scope of chiral ɑ-amino acids.
From: Stereoselective diversification of α-amino acids enabled by N-heterocyclic carbene catalysis
Reaction conditions: A mixture of ɑ-AAs 1 (0.05 mmol), diphenylmethanol 2a (0.075 mmol), NHC-3a (20 mol%), Cs2CO3 (0.05 mmol) and DIC (0.06 mmol) dissolved in DCM (0.05 M) was stirred at r.t. for 2–4 h. Isolated yields are presented. Chiral HPLC determined ee values. a NHC-3s was applied instead of NHC-3a.
