Fig. 2: The molecular mechanism of FIP200 and ATG16L1 interaction.
From: Molecular bases of the interactions of ATG16L1 with FIP200 and ATG8 family proteins
a Ribbon diagram showing the overall structure of the dimeric FIP200 Claw/ATG16L1 FIR complex. In this drawing, two FIP200 Claw molecules are colored in orange and marine, while two bound ATG16L1 FIR motifs are colored in magenta and hot pink, respectively. b Ribbon representation showing the structural comparison of apo-form FIP200 Claw dimer (green, PDB ID: 6DCE) with the FIP200 Claw/ATG16L1 FIR complex (blue/magenta). In this drawing, the two dimeric structures are overlaid by aligning selected one FIP200 Claw monomer in these two structures. c Ribbon-stick model showing the detailed interactions between FIP200 Claw and ATG16L1 FIR. The hydrogen bonds and salt bridges involved in the interaction are shown as dotted lines. d The combined surface charge representation and the ribbon-stick model showing the charge-charge interactions between FIP200 Claw and ATG16L1 FIR in the solved complex structure.
