Fig. 2: Reaction discovery. | Nature Communications

Fig. 2: Reaction discovery.

From: Catalyst-controlled stereodivergent synthesis of polysubstituted alkenes

Fig. 2

Identification of the optimal reaction conditions. NiCl2·DME (5 mol %), L (5 mol %), 1 (0.4 mmol, 1.0 equiv.), 2 (0.8 mmol, 2 equiv.), 3 (0.6 mmol, 1.5 equiv.), and LiOMe (0.8 mmol, 2 equiv.) in 1,4-dioxane (2.0 mL), stirred at 40 oC for 12 h. GC yields, syn:anti selectivities were determined by GC analysis of the crude reaction mixture. +3 (0.8 mmol, 2.0 equiv).

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