Fig. 3: Scope of the syn-selective carboboration reaction.
From: Catalyst-controlled stereodivergent synthesis of polysubstituted alkenes
General reaction conditions: alkyne (0.4 mmol, 1.0 equiv.), B2pin2 (2.0 equiv.), alkyl bromide (1.5 equiv.), NiCl2·DME (5 mol%), L4 (5 mol%), LiOMe (2.0 equiv.) in 1,4-dioxane (0.2 M) was at 40 oC stirred for 12 h. The given isolated yields refer to the single isomeric product; syn:anti selectivities were determined by GC analysis of the crude reaction mixtures. a L9 (6-methyl-2,2’-bipyrdine) was used. b CPME was used. c L5 was used.
