Fig. 2: Depletion of Alkbh8 reduces intestinal epithelium proliferation.
From: ALKBH8-mediated codon-specific translation promotes colorectal tumorigenesis
a Immunofluorescence staining of ALKBH8 in duodenum, jejunum, ileum, and colon sections of mice. b Immunofluorescence co-staining of ALKBH8 with DCLK1, MUC2, Ki67, LYZ, and LGR5 in duodenum sections of mice. c Schematic of Alkbh8 conditional knockout (Alkbh8cKO) mouse. d The representative jejunum from wild-type (Alkbh8CTL) and Alkbh8cKO mice. Left: hematoxylin and eosin staining (H&E); middle: BrdU staining; right: quantification of crypt height and BrdU+ cells. e The representative colon from wild-type (Alkbh8CTL) and Alkbh8cKO mice. Left: hematoxylin and eosin staining (H&E); middle: BrdU staining; right: quantification of crypt height and BrdU+ cells. Mean ± SEM, 6 biological replicates, two-sided t-test. Source data are provided as a Source Data file.
