Fig. 2: Bursts in sensory-evoked cortical output by PTs.
From: Thalamus enables active dendritic coupling of inputs arriving at different cortical layers
a Left: schematic of our experiments in anesthetized rats. The schematic of the rat was adapted and modified from “Diamond ME, von Heimendahl M, Knutsen PM, Kleinfeld D, Ahissar E. ‘Where’ and ‘what’ in the whisker sensorimotor system. Nat Rev Neurosci 9, page 602, 2008, Springer Nature”68. Reproduced with permission from Springer Nature. Right: example recording for one of the PTs in Fig. 1c (most right). The trace shows somatic APs recorded during four example trials in which we deflected the whiskers by a low-pressure airpuff. Gray boxes denote the first 50 ms after stimulus onset for which we analyzed sensory-evoked responses. b Example trials for the PT from panel a show three types of sensory-evoked responses. c Latencies of sensory-evoked local field potentials (LFPs) show that TC input reaches L5/6 and L4 (n = 62 recording depths) before the onsets of sensory-evoked bursts by PTs. d Burst rates pre and post whisker deflections (n = 25 PTs). Box plots represent medians and 25th to 75th percentiles. Whiskers extend to 1.5 times the interquartile range. The asterisk represents 2-sided t Test, unpaired, heteroscedastic, p = 0.026). e Post-stimulus-time-histograms (PSTHs) for TC neurons in VPM (n = 8), L2/3PNs (n = 8), L4SPs (n = 10), L5ITs (n = 9), PTs (n = 25), L6CCs (n = 7) and L2-6 INHs (n = 22). f Latencies of sensory-evoked APs in L6CCs, L4SPs and PTs. Source data for panels (c–f) are provided in the Source Data file.
