Fig. 7: Dopaminergic (DA) neuronal-microglial (MG) differentially expressed gene (DEG) subclusters showing added functional impacts for SUD+HIV+u donors. | Nature Communications

Fig. 7: Dopaminergic (DA) neuronal-microglial (MG) differentially expressed gene (DEG) subclusters showing added functional impacts for SUD+HIV+u donors.

From: Transcriptional impacts of substance use disorder and HIV on human ventral midbrain neurons and microglia

Fig. 7

a Dendrogram relating DA and MG DEGs for the differential expression analysis (DEA) comparing SUD+HIV+u vs. SUD−HIV+u donors (Fig. 2b, h); the two subclusters shown in (c–f) are labeled. b Dendrogram relating DEGs for SUD+HIV+u vs. SUD+HIV− (Figs. 3a and 5a); the subcluster shown in (g, h) is labeled. c, d DEG list and pairwise similarities for subcluster C16S2. c Subcluster C16S2 DEGs organized by functional group; color at right serves as a group index used with (d); color at left indicates type of effect following Fig. 6b. M. sim: subcluster mean pairwise similarity. d Heatmap showing subcluster C16S2 DEGs arranged by similarity, with element color corresponding to pairwise DEG correlations. Colors below DEG names correspond to functional group indices as in (c). e, f Similar to (c, d) but for subcluster C17S0, and with functional group indices from (e) to the right of DEG names in (f). g, h Similar to (e, f) but for subcluster C6S0.

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