Fig. 7: TAF4A protects genome stability of MuSCs by enabling NSL-dependent acetylation of lamin A/C. | Nature Communications

Fig. 7: TAF4A protects genome stability of MuSCs by enabling NSL-dependent acetylation of lamin A/C.

From: Regulation of NSL by TAF4A is critical for genome stability and quiescence of muscle stem cells

Fig. 7

TAF4A drives expression of Kansl2 by interacting with the NF-Y complex. KANSL2 is a critical part of the NSL (non-specific lethal) complex, which also comprises the acetyl-transferase MOF. Decreased expression of Kansl2 prevents NSL-mediated acetylation of Lamin, increasing Lamin phosphorylation and solubility. Created in BioRender. Guo, X. (2025) https://BioRender.com/frmva1q.

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