Fig. 2: SARS-CoV-2 infection modifies expression of small noncoding RNAs found in the mature spermatozoa at 4-weeks post-infection. | Nature Communications

Fig. 2: SARS-CoV-2 infection modifies expression of small noncoding RNAs found in the mature spermatozoa at 4-weeks post-infection.

From: Paternal SARS-CoV-2 infection impacts sperm small noncoding RNAs and increases anxiety in offspring in a sex-dependent manner

Fig. 2

A Circular heatmap (Log2fold-change) of protract-identified total piRNA clusters (B) Heatmap displaying the relative expression of the differentially expressed piRNA clusters across all biological replicates (each biological replicate contains RNA pooled from 3 animals; n = 5 CON, n = 4 SARS). C MA (Bland-Altman) plot of the Log2(average expression + 1) for each piRNA cluster vs. Log2 fold-change relative to control values for each cluster (MA plot shows differences in expression between control and SARS-CoV-2 treatment groups for each gene) (D) Heatmap displaying differentially expressed miRNA and tsRNA across all biological replicates (FDR < 0.05) (E) Gene ontology analysis of predicted gene targets (miRNA and tsRNA) reveals pathways associated with molecular function, cellular components, and biological processes to be significantly enriched (FDR < 0.05).

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