Fig. 2: Re-analysis of scRNA-seq data from pancreas of healthy and type 1 diabetic donors.
From: The Hippo terminal effector YAP boosts enterovirus replication in type 1 diabetes
A UMAP visualization of cells colored by diabetic status (ND = Non-Diabetic, T1D = Type 1 Diabetes). B UMAP showing the sample sources from the Gaulton study (nPOD: Network for Pancreatic Organ Donors with Diabetes, UPenn: University of Pennsylvania). C UMAP representation of original study-defined cell types. D Dot plot of the top ten significantly enriched GO Biological Process (GO BP) terms in β-cells (T1D vs. ND). E Dot plot of T1D-relevant pathways (GO BP) significantly enriched in β-cells (T1D vs. ND). F GSEA of YAP target genes and Hippo signaling pathway in β-, alpha-, ductal-, and activated stellate cells. GSEA was performed using the GSEAPY tool with the GO Biological Process 2023 gene sets, applying a Kolmogorov–Smirnov-like enrichment score. Statistical significance was assessed via permutation testing followed by false discovery rate (FDR) correction.
