Fig. 6: Competitive potential for colonization of the gastrointestinal tract in mice. | Nature Communications

Fig. 6: Competitive potential for colonization of the gastrointestinal tract in mice.

From: Parallel within-host evolution alters virulence factors in an opportunistic Klebsiella pneumoniae during a hospital outbreak

Fig. 6

a 3 × 107 CFU of 1:1 mixes of index and the respective test isolates were given by oral gavage at Day 0, 1, and 5. Overall CFU/g in faeces for each mouse (n = 35) is plotted during the 10-day experiment. On Day 5, clindamycin was added to the drinking water after a third oral gavage with bacteria. b Top panel illustrates phenotypes for each isolate. The lower panel displays competitive indices during days 6-10 of gastrointestinal colonization. Competitive index >0 means an advantage of the tested isolate versus the index isolate DA14734, <0 – disadvantage. Dots show the competitive index in individual mice (n = 6 per competition), and the trendline connects the means. Comparisons to control competition on each day were made by unpaired two-tailed t-test; Bonferroni corrected (5 comparisons) two-tailed p-values exceeding significance (p < 0.05) are shown above datapoints. Source data are provided as a Source Data file.

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