Table 1 Overview of non-cardiometabolic type 2 diabetes comorbidities GWAS

From: The effect of type 2 diabetes genetic predisposition on non-cardiovascular comorbidities

Disease

Genetic ancestry

N

Ncases

Ncontrols

Cases definition

Ref.

SR

CD

Alzheimer’s disease

EUR

63,936

21,982

41,954

 

x

80

Anorexia nervosa

EUR

72,517

16,992

55,525

x

x

81

Asthma

EUR

1,376,071

121,940

1,254,131

x

x

82

EAS

341,204

18,549

322,655

x

x

82

AMR

18,173

4069

14,104

x

x

82

SAS

27,091

4015

23,076

x

x

82

AFR

32,658

5051

27,607

x

x

82

ADHD

EUR

225,534

38,691

186,843

 

x

83

Autism

EUR

46,350

18,381

27,969

 

x

84

Back pain

EUR

158,025

29,531

128,494

x

x

85

Bipolar disorder

EUR

413,466

41,917

371,549

 

x

86

CTS

EUR

1,239,680

48,843

1,190,837

 

x

87

Cataracts

EUR

585,243

67,844

517,399

 

x

88

COPD

EUR

995,917

58,559

937358

x

x

89

AFR

29,682

1978

27,704

x

x

89

AMR

15,086

1503

13,583

x

x

89

EAS

329,733

19,044

310,689

x

x

89

Depression

EUR

404,529

170,756

233,773

x

x

90

EAS

382,936

21,980

360,956

x

x

91

AMR

377,959

25,013

352,946

x

x

91

SAS

31,681

4505

27,176

x

x

91

AFR

198,497

36,818

161,679

x

x

91

Epilepsy

EUR

82,482

29,944

52,538

 

x

92

Erectile dysfunction

EUR

223,805

6175

217,630

x

x

93

Glaucoma

EUR

379,422

29,241

350,181

x

x

94

OCD

EUR

9725

2688

7037

 

x

95

Osteoarthritis

EUR

826,690

177,517

649,173

x

x

96

Osteoporosis

EUR

488,501

8520

479,981

 

x

97

EAS

178,726

9794

168,932

 

x

97

PCOS

EUR

120,023

5209

114,814

 

x

98

Rheumatoid arthritis

EUR

97,173

22,350

74,823

 

x

99

EAS

173,633

11,025

162608

 

x

99

Schizophrenia

EUR

130,644

53,386

77,258

 

x

100

EAS

30,761

14,004

16,757

 

x

100

AFR

10,070

6152

3918

 

x

100

AMR

4324

1234

3090

 

x

100

Vascular dementia

EUR

466,606

3892

462,714

 

x

101

  1. The overview includes genetic ancestry defined based on the continental super populations of the 1000 Genomes Project phase 339 (AMR = Admixed American; AFR = African; EAS = East Asian; EUR = European; SAS = South Asia), total sample size (N), number of cases (Ncases), number of controls (Ncontrols), case definition (SR = self-reported; CD = clinically diagnosed) and the corresponding GWAS publication. (ADHD = attention-deficit/hyperactivity disorder; COPD = chronic obstructive pulmonary disease; CTS = Carpal tunnel syndrome; OCD = obsessive-compulsive disorder; PCOS = polycystic ovary syndrome).