Fig. 6: A cortico-subcortical circuit for matching behavioural policies to the environment.
From: Activity in human dorsal raphe nucleus signals changes in behavioural policy
a Diagram of proposed circuit interactions between the cortex and dorsal raphe nucleus (DRN) during reward-guided decision-making. In tandem with previous studies, we propose that regions of cortex like the dorsal anterior cingulate cortex (dACC) and anterior insula (AI) compute the relative value of reward options given the environment, and the DRN implements and/or facilitates changes in behavioural policy arising from relative value computations. b Psychophysiological interaction between dACC and DRN as a function of environment-type. Line and shading indicate mean ± SE of regression weight across participants; n = 27; *p < 0.05, **p < 0.01, ***p < 0.001 two-tailed.
