Fig. 2: Exercise training improved health-related metabolic parameters similarly among all diet treated groups. | Nature Communications

Fig. 2: Exercise training improved health-related metabolic parameters similarly among all diet treated groups.

From: A ketogenic diet enhances aerobic exercise adaptation and promotes muscle mitochondrial remodeling in hyperglycemic male mice

Fig. 2

A Daily running distance (CON-CHOW n = 13, STZ-CHOW n = 15, STZ-KETO n = 15), and B circadian running patterns were similar among groups (CON-CHOW n = 5, STZ-CHOW n = 7, STZ-KETO n = 7). C Training improved random blood glucose (P = 0.0004, Sedentary: CON-CHOW n = 16; STZ-CHOW n = 15; STZ-KETO n = 15, Exercise-trained: CON-CHOW n = 13; STZ-CHOW n = 14; STZ-KETO n = 14) and D glucose tolerance (P = 0.0004, Sedentary n = 12/group, Exercise-trained: CON-CHOW n = 11; STZ-CHOW n = 9; STZ-KETO n = 10) in all groups. E Blood ketones were decreased by training (P = 0.0019), but still remained higher in STZ-KETO (P < 0.0001, n = 8/group). F Body mass was higher in sedentary STZ-KETO (P = 0.0176), but was reduced to the level of controls by exercise-training (P < 0.0001). G Fat mass was higher in sedentary STZ-KETO, but was reduced to the level of controls with exercise-training (P < 0.0001). H Percent lean mass was increased by exercise training in all groups (P < 0.0001). For F–H Sedentary: CON-CHOW n = 15; STZ-CHOW n = 15; STZ-KETO n = 13, Exercise-trained: CON-CHOW n = 13; STZ-CHOW n = 14; STZ-KETO n = 13. Gray circles represent CON-CHOW, blue circles represent STZ-CHOW, and orange circles represent STZ-KETO. Data from (A–H) are presented as mean ± SEM. Panels C-H were analyzed by 2-way ANOVA with Tukey post-hoc testing. Source data are provided as a Source Data file.

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