Extended Data Fig. 5: Transcriptome analysis of TOP1α and TOR regulated genes.
From: TOP1α fine-tunes TOR-PLT2 to maintain root tip homeostasis in response to sugars
a, Venn diagram showing the number of overlapping TOR-activated and TOR-repressed as well as Glc-TOR-activated and Glc-TOR repressed DEGs identified by Xiong et al., (2013). b, Venn diagram showing the number of overlapping DEGs in top1α vs. Ler and AZD-8055-treated Ler vs. Ler (left); and overlapping DEGs in top1α vs. Ler and AZD-8055-treated top1α vs. top1α (right). c, GO analysis of TOR-activated genes (upper panel) and TOR-repressed genes (lower panel). d, GO analysis of TOP1α-activated genes (left) and TOP1α-repressed genes (right). e, f, Hierarchical clustering analysis of TOR-activated (e) and TOR-repressed genes (f). TOR-activated and TOP1α-repressed DEGs (e) and TOR-repressed and TOP1α-activated DEGs (f) were grouped and subjected to GO analysis, as shown in the graphs. g, h, Hierarchical clustering analysis of TOP1α-activated (g) genes and TOP1α-repressed genes (h). TOP1α-activated and TOR-repressed DEGs (g) and TOP1α-repressed and TOR-activated DEGs (h) were grouped and subjected to GO analysis, as shown in the graphs. The GO enrichment analysis was performed by R package ClusterProfiler3.0, in which the pvalue was calculated by Fisher’ exact test, and was adjusted by Benjamini-Hochbery method in c-h.
