Extended Data Fig. 9: Different effects of BAS, SAS and MAS mutations on chromatin accessibility.

a, The number of differential accessible regions (DARs) in indicated SWI/SNF mutants. DARs with increased accessibility (ATAC-up) were represented in red and DARs with decreased accessibility (ATAC-down) were represented in blue. b, The percentage of BAS/SAS/MAS-bound and unbound regions among the regions with decreased accessibility (ATAC-down regions) in corresponding BAS/SAS/MAS mutants. c, The number of genes with increased accessibility and genes with decreased accessibility in indicated SWI/SNF mutants. Genes with increased accessibility (ATAC-up) were represented in red and genes with decreased accessibility (ATAC-down) were represented in blue. d, Boxplots showing H3K27me3 levels at the regions bound by each complex and the regions bound by each complex with decreased (ATAC-down) or maintained (ATAC-maintain) accessibility. The sample size of each box plot: BAS-bound (n = 12392), ATAC-down (n = 1470), ATAC-maintain (n = 10922), SAS-bound (n = 11398), ATAC-down (n = 2195), ATAC-maintain (n = 9203), MAS-bound (n = 11129), ATAC-down (n = 1637), ATAC-maintain (n = 9492), random (n = 10000). In box plots, center lines and box edges are medians and the interquartile range (IQR), respectively. Whiskers extend within 1.5 times the IQR. P values determined by two-tailed Mann Whitney U test indicate the difference between indicated samples.