Extended Data Fig. 8: Generation of Mpice2 mutants by CRISPR/Cas9.

a, Schematic representation of the MpICE2 gene and the resulting mutations in the obtained CRISPR/Cas9-generated alleles. Gray, white, and blue boxes indicate the coding sequences (CDS), the untranslated regions (UTR), and the bHLH domain coding region, respectively. b, Sequence alignment of putative translational products of wild type (WT) and Mpice2^ge mutants. Asterisks indicate the amino acids that are assumed to be important for binding to the E-box.