Extended Data Fig. 8: Sequence and functional analysis of histone acetylation-binding activity of GTE7.

a. Sequence alignment of bromodomains of GTE2, GTE7, BRD4, CBP, P300 and PCAF. Two conserved residues of Tyr and Asn are shown in red box. b. Metaplots show the GTE7 and GTE72A enrichment level on GTE2/7-enriched genes under heat condition. c. Additional biological replicate for Fig. 7a showing ChIP-qPCR analysis of CDKL9 enrichment on genes in wild-type and gte2/7 mutant backgrounds (n = 2 technical replicates). d. Additional biological replicate for Fig. 7b showing ChIP-qPCR analysis of CDKL9 enrichment on genes in wild-type and GTE72A-rescued gte2/7 mutant backgrounds (n = 2 technical replicates).