Fig. 7
From: An alanine expanded PABPN1 causes increased utilization of intronic polyadenylation sites
Utilization of polyadenylation signal motifs in switch regions. a Density histograms of p-values of PAS motif distribution in switch or default PAS regions. Analysis was stratified for downstream and upstream switches. In each group motif frequency was compared to the frequency of all PASs, and statistical significance was assessed with Pearson’s chi-square test. p-values obtained by comparing between motifs distribution in 1000 random subsets of PASs and motifs distribution of all PASs. The red line shows the calculated p-value for each group. b The ratio between switch (A17.1) and default (FVB) PAS utilization regions for 13 polyadenylation signal motifs. Numerical values are shown in Supplementary Table S4. Downstream or upstream switches are depicted by open circles or closed squares, respectively. Hashed line marks ratio = 1. Canonical motifs are underlined. Arrows mark motifs with consistent switches in A17.1 mice: up arrows represents more utilized in A17.1 and down arrow less utilized in A17.1. c Bar chart shows the proportion of genes with up/down or unchanged expression in each PAS motif
