Fig. 3
From: SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes
Lipid accumulation and senescence induction in SMARCD1-silenced HepG2 cells. (a) SMARCD1 relative expression in SMARCD1-silenced HepG2 cells. (b) Expression of SMARCD1 in scr-shRNA-transduced and SMARCD1-silenced HepG2 cells. PPAR-dependent transcription (c) and transcriptional activation ability of PGC-1α (d) in scr-shRNA-transduced and SMARCD1-silenced HepG2 cells. (e) Relative expression of FAO genes in scr-shRNA-transduced and SMARCD1-silenced HepG2 cells. (f) The number of lipid droplet in scr-shRNA-transduced and SMARCD1-silenced HepG2 cells. (g) Activity and expression of senescence markers were measured in scr-shRNA-transduced and SMARCD1-silenced HepG2 cells. Data are expressed as mean ± SD. P < 0.05 was considered statistically significant (* P < 0.05; ** P < 0.01; *** P < 0.001)
