Fig. 5: Untargeted metabolomics analysis on the effect of global NQO1 overexpression in several tissues and serum of WT and NQO1-Tg mice-fed SD or HFD.
From: NQO1 protects obese mice through improvements in glucose and lipid metabolism
a Two-way Venn-diagrams depicting the distribution of unique and common metabolites in WT and NQO1-Tg mice-fed HFD vs. SD. Untargeted metabolomics analysis was carried out in liver, skeletal muscle (SKM), visceral WAT (vFAT) and serum. Upregulation (red font), downregulation (blue font), and reciprocal regulation (black font) of significantly impacted metabolites (defined as fold-change >1.5 or <0.67) are depicted. b Distribution of various classes of lipids (e.g., NEFAs, MAGs, DAGs, ceramides, PUFAs, hydroxy FAs) in the indicated tissues and serum of WT and NQO1-Tg mice-fed HFD vs. SD. c Heatmap visualization of metabolites in serum (left) and liver (right) of WT and NQO1-Tg mice-fed SD or HFD. Upregulation (red font), downregulation (green font).
