Fig. 7: Working model illustrating cooperative regulation of carnitine acetyltransferase (CRAT) activity coupled with SIRT3-mediated removal of the excess mitochondrial protein acetylation in the liver of NQO1-Tg mice-fed high-fat diet (HFD).
From: NQO1 protects obese mice through improvements in glucose and lipid metabolism
NQO1 transgenesis increases the availability of NAD+, an essential cofactor for SIRT3 activity.
