Table 2 Quantification of regions of interest MR images.

From: Impact of age on the circadian visual system and the sleep-wake cycle in mus musculus

	Age	Volume (mm³)	Statistics	Significance	Percentage (%)	Statistics	Significance
Whole	Young	218.73 ± 9.9	t(8) = 1.759	p = 0.117
Whole	Old	240.18 ± 7.14
Learning/Memory regions
CTX	Young	71.03 ± 1.96	t(8) = 0.759	p = 0.470	32.51 ± 0.48	t(8) = 3.277	p = 0.011*
CTX	Old	68.63 ± 2.48			28.66 ± 1.06
OB	Young	9.43 ± 0.56	t(7) = 1.378	p = 0.211	4.11 ± 0.21	t(7) = 0.006	p = 0.995
OB	Old	10.29 ± 0.44			4.32 ± 0.26
HIP	Young	12.37 ± 0.46	t(8) = 3.800	p = 0.005*	5.67 ± 0.26	t(8) = 4.226	p = 0.003*
HIP	Old	10.09 ± 0.38			4.23 ± 0.22
CP	Young	12.09 ± 0.53	t(8) = 0.513	p = 0.622	5.53 ± 0.20	t(8) = 1.137	p = 0.288
CP	Old	12.45 ± 0.45			5.20 ± 0.21
CB	Young	31.44 ± 1.02	t(7) = 3.556	p = 0.009*	14.06 ± 0.56	t(7) = 3.787	p = 0.007*
CB	Old	27.07 ± 0.63			11.32 ± 0.41
BLA	Young	2.33 ± 0.32	t(8) = 1.252	p = 0.246	0.32 ± 0.04	t(8) = 2.060	p = 0.073^†
BLA	Old	1.92 ± 0.11			0.24 ± 0.01
Circadian visual regions
opt	Young	2.07 ± 0.04	t(4) = 5.814	p = 0.004*	0.27 ± 0.01	t(4) = 3.484	p = 0.025*
opt	Old	3.32 ± 0.16			0.40 ± 0.03
dLGN	Young	2.44 ± 0.12	t(8) = 2.525	p = 0.036*	0.33 ± 0.03	t(8) = 2.975	p = 0.025*
dLGN	Old	2.03 ± 0.11			0.25 ± 0.01
vLGN	Young	0.79 ± 0.05	t(8) = 0.161	p = 0.876	0.11 ± 0.01	t(8) = 0.878	p = 0.406
vLGN	Old	0.8 ± 0.05			0.10 ± 0.004
EPI	Young	1.05 ± 0.08	t(8) = 1.928	p = 0.090^†	0.14 ± 0.02	t(8) = 2.557	p = 0.034*
EPI	Old	0.83 ± 0.08			0.10 ± 0.01
SC	Young	4.63 ± 0.11	t(8) = 1.644	p = 0.139	0.63 ± 0.02	t(8) = 3.072	p = 0.015*
SC	Old	4.12 ± 0.28			0.51 ± 0.03

CTX cortex, OB olfactory bulb, HIP hippocampus, CP caudate nucleus, CB cerebellum, BLA basolateral amygdala, opt optic tract, dLGN dorsal lateral geniculate nucleus, vLGN ventral lateral geniculate nucleus, EPI habenula, SC superior colliculus.
*Bolded and statistical significance at p < 0.05.
^†Trend toward significance p < 0.10.

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