Table 1 Hemodynamic data and plasma cholesterol levels of WT and ApoE-/- mice.

From: Simvastatin therapy attenuates memory deficits that associate with brain monocyte infiltration in chronic hypercholesterolemia

Physiological parameter

ApoE-/- young (4 months)

ApoE-/- aged (12 months)

WT young (4 months)

WT aged (12 months)

BPsys (mmHg)

104.8 ± 2.8

133.2 ± 4.4*

99.4 ± 3.4

114.6 ± 1.7*

HR (bpm)

489.1 ± 9.1

557.2 ± 11.0*

458.9 ± 17.7

556.9 ± 11.3*

Cholesterol (mg/L)

98.3 ± 2.4

181.7 ± 6.1*

74.2 ± 0.8&

99.8 ± 2.6*&

Heart–body weight ratio

5.03 ± 0.19

5.91 ± 0.26*

5.34 ± 0.13

5.48 ± 0.27

  1. Systolic blood pressure and heart rate were measured in conscious mice using tail cuff plethysmography. Heart–body weight ratio calculated from animal weight (g) and respective heart weight (mg). Cholesterol levels were determined in plasma obtained from anesthetized mice by ELISA. ApoE apolipoprotein E, BPsys systolic blood pressure, bpm beats per minute, BW body weight, HR heart rate, WT wild-type. Values are expressed as mean ± SEM. N denotes number of independent biological replicates. N = 10 per group; * denotes P ≤ 0.05 relative to respective young, & denotes P ≤ 0.05 relative to aged mice of respective other group after two-way ANOVA followed by Sidak post hoc test.
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