Table 3 Hemodynamic data and plasma cholesterol levels of ApoE-/- mice post treatment.

From: Simvastatin therapy attenuates memory deficits that associate with brain monocyte infiltration in chronic hypercholesterolemia

Physiological parameter

ApoE-/- young (4 months)

ApoE-/- aged (14 months)

ApoE-/- aged + hydralazine

ApoE-/- aged + simvastatin

ApoE-/- aged + hydralazine/simvastatin

BPsys (mmHg)

107.3 ± 3.1

136.9 ± 5.8*

110.1 ± 1.9&

105.4 ± 1.6&

112.6 ± 1.5&

HR (bpm)

491.1 ± 9.7

569.9 ± 8.6*

514.3 ± 10.9

512.2 ± 18.3

520.0 ± 12.9

Cholesterol (mg/L)

99.8 ± 4.3

184.7 ± 5.3*

227.9 ± 13.6*

108.7 ± 2.6*&

187.4 ± 13.4*

Heart–body weight ratio

4.59 ± 0.06

5.53 ± 0.21*

5.27 ± 0.16*

4.67 ± 0.56&

5.31 ± 0.22*

  1. Systolic blood pressure and heart rate were measured in conscious mice using tail cuff plethysmography. Heart–body weight ratio calculated from animal weight (g) and respective heart weight (mg). Cholesterol levels were determined in plasma obtained from anesthetized mice. ApoE apolipoprotein E, BPsys systolic blood pressure, bpm beats per minute, BW body weight, HR heart rate. Values are expressed as mean ± SEM. N denotes number of independent biological replicates; N = 10 per group and N = 8 for aged ApoE-/- treated with hydralazine/simvastatin combined; * denotes P ≤ 0.05 relative to young control, & denotes P ≤ 0.05 relative to aged group after one-way ANOVA followed by Tukeyer post hoc testing.
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