Fig. 1: NR treatment increases lymphoid-progenitor cell frequencies in Atm−/− bone marrow. | npj Aging and Mechanisms of Disease

Fig. 1: NR treatment increases lymphoid-progenitor cell frequencies in Atm−/− bone marrow.

From: NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm−/− and old mice HSCs

Fig. 1

a–c Frequency analysis of early progenitor compartments in NR-treated (NR) or untreated bone marrow from Atm+/+ (WT) or Atm−/− (ATM) mice (2–3 months). CLP common lymphoid progenitors (Lin−IL-7Rα+Flk2+), LSK lineage−Sca1+c-Kit+, HSC Lin−c-Kit+Sca1−CD34−Flk2−. d Composition of the LSK compartment. e Frequencies of lineage-biased subsets of HSCs defined by Slamf1(CD150) expression. Data are represented as mean ± SEM. n: 4–6. Kruskal–Wallis test for a–c, two-way ANOVA for d and e. q value (Kruskal–Wallis test) or p value (two-way ANOVA): <0.05*, <0.01**, <0.001***.

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