Table 2 Association between healthy ageing associated genetic loci and 7 individual domains addressed by healthy ageing.

From: Genetic associations with healthy ageing among Chinese adults

 

rs138499810

rs117898573

TA

P

PAdj

OR (95% Cl)

TA

P

PAdj

OR (95% Cl)

No limitation in instrumental activities of daily living1

T

0.112

1.000

1.348 (0.933, 1.950)

T

0.670

1.000

1.067 (0.793, 1.435)

No function-limiting pain2

0.031

0.282

1.498 (1.037, 2.164)

0.001

0.010

1.623 (1.212, 2.173)

No impairment of cognitive function3

0.629

1.000

1.121 (0.704, 1.786)

0.062

0.562

1.406 (0.982, 2.012)

No clinical depression at screening4

0.155

1.000

1.275 (0.912, 1.782)

0.078

0.700

1.281 (0.973, 1.686)

No history of major chronic diseases5

0.014

0.127

1.463 (1.080, 1.983)

0.004

0.033

1.451 (1.128, 1.866)

Good physical function6

0.814

1.000

0.940 (0.560, 1.577)

0.130

1.000

1.351 (0.915, 1.994)

Good overall self-perceived health7

8.68 × 10−4

7.81 × 10−3

1.639 (1.226, 2.193)

0.051

0.455

1.270 (0.999, 1.614)

  1. TA test allele, OR Odds ratio, Cl Confidence interval.
  2. 1Cases defined as IADL score >8.
  3. 2Cases defined as those who reported having no pain or discomfort.
  4. 3Cases defined as MMSE score ≥18 for participants with no formal education; ≥21 for primary school education; ≥25 for secondary school or higher.
  5. 4Cases defined as a GDS-15 score <5.
  6. 5Cases defined as no history of cancer, myocardial infarction, angina, heart failure, coronary artery bypass graft or angioplasty, stroke, diabetes, kidney failure, Parkinson’s disease, and chronic lung diseases.
  7. 6Cases defined as those who reported having no problem with mobility, self-care, and usual activities.
  8. 7Cases defined as those who rated their health as good or excellent.
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