Table 1 Liver NAD+ metabolome profile in rats.
Group mean (pmol/mg) | Main effect of diet | Main effect of treatment | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
CD-VE | CD-NR | HFD-VE | HFD-NR | % change from CD | 95% CI | FDR adj. p-value | % change from VE | 95% CI | FDR adj. p-value | |
ADPR | 81.6 | 49.4 | 61.1 | 31 | −29.6 | (−68.9 to −7.3) | 0.041 | −43.5 | (−83.1 to −19.9) | 0.001 |
Me2PY/Me4PY | 0.4 | 4.7 | 0.4 | 13.7 | 104.7 | (8.1 to 287.6) | 0.11 | 1447.1 | (718.7 to 2823.6) | 3.39E-07 |
MeNam | 0 | 0 | 0 | 0 | 16.9 | (−17.2 to 65) | 0.464 | −18.3 | (−42.1 to 15.2) | 0.381 |
NA | 0 | 0.1 | 0 | 0.2 | 78.2 | (−36.6 to 400.6) | 0.392 | 90.5 | (−32 to 433.3) | 0.381 |
NAAD | 0.2 | 0.9 | 0.3 | 0.8 | 39.2 | (−19.5 to 140.7) | 0.381 | 207.8 | (78.4 to 431.2) | 0.003 |
NAADP | 0 | 0 | 0 | 0 | −10.8 | (−60.2 to 11.9) | 0.517 | −18.4 | (−68.8 to 5.6) | 0.31 |
NAD+ | 437.4 | 748.5 | 591.8 | 756.6 | 25.3 | (−4.5 to 64.3) | 0.259 | 45.8 | (11.3 to 91.1) | 0.044 |
NADP+ | 117.9 | 111.7 | 120.9 | 134.2 | 10.9 | (−17.2 to 25.7) | 0.452 | 3.7 | (−26 to 19.7) | 0.73 |
NAM | 372.5 | 420.8 | 326.6 | 333.1 | −16.8 | (−56.1 to 4.2) | 0.286 | 7.3 | (−27.2 to 24.2) | 0.573 |
NAMN | 0.8 | 1.4 | 1.1 | 1.5 | 17.8 | (−26.9 to 34.9) | 0.392 | 51.1 | (27.7 to 58.6) | 0.044 |
NAR | 0.8 | 1.1 | 0.7 | 0.9 | −10.9 | (−89.1 to 16.5) | 0.573 | 36.5 | (−19 to 50.3) | 0.259 |
NMN | 21.7 | 30.8 | 28.4 | 37 | 16.7 | (−22.2 to 75.1) | 0.517 | 43.8 | (−4 to 115.4) | 0.246 |
NR | 8.4 | 11.7 | 7.7 | 10.2 | −10.7 | (−88.8 to 16.6) | 0.573 | 34.8 | (−22.2 to 49.2) | 0.266 |
