Table 1 Components of NT and target points of interaction with the cellular processes that influence cellular NAD⁺ content.

Nicotinamide

500 mg

Substrate for NAD⁺ synthesis (salvage pathway)

Alpha lipoic acid

600 mg

Activate NAMPT through activation of AMPK^38,39; activate NQO1 to promote oxidation of NADH to NAD⁺⁴⁰, reduce production of free radicals⁴¹; antioxidant⁴²

Zinc

10 mg

Antioxidant; support immune function^43,44

Vitamin C

20 mg

Botanical blend comprising:

2110 mg

Green tea extract (providing Epigallocatechin gallate (EGCG) and other catechins)

Reduce expression of NNMT⁴⁵, which methylates NAM to excreted product MeNAM⁴⁶.

Rutin (providing Quercetin and Troxerutin)

Increase activity of NAMPT (rate-limiting enzyme in salvage pathway)^47,48;

Parsley leaf extract (providing apigenin)

Inhibits CD38⁴⁹ (primary NAD+ hydrolase)

Black pepper fruit extract

To enhance oral bioavailability of phytonutrients⁵⁰