Fig. 4: Aging-associated cancer risk of selected hub genes.
a Top 20 hub genes of 3 selected patterns (PT_1, PT_2 and PT_4). The 1st to 4th column indicate the hub gene rank, score, annotated result from pairwise analysis and the gene symbol. b 3 pattern hub genes that have annotated information from the 2 public database. c Annotated genes from 4 patterns of time-series analysis. Heatmap visualized with z-scaled normalized value of time-series analysis. Inverse log p value of the analysis are visualized with bar plot. A-gene: aging genes, O-gene: oncogene, S-gene: tumor suppressor gene, F-gene: fusion gene, C-gene: cell-age gene. A- ang C-gene information were from GenAge database and O-, S- and F-gene are from Cancer Census database. Inverse log p value of adjoining pairwise DEG analysis are visualized with up DEG colored red and down DEG colored blue. d TCGA(Acute Myeloid Leukemia)-GTEx(normal) gene expression data comparison of top 10 hub genes. Significant difference was calculated by two-tailed Mann-Whitney test with bonferroni correction. ns: 5.00e-02 < p <= 1.00e + 00, *: 1.00e-02 < p <= 5.00e-02, **: 1.00e-03 < p <= 1.00e-02, ***: 1.00e-04 < p <= 1.00e-03, ****: p <= 1.00e-04. Source data are provided as a Source Data Fig. 4 file.
