Table 2 Multivariable-adjusted mean values of the volumes of the hippocampus and hippocampal subregions according to hemoglobinA1c levels

From: Glucose metabolism and smaller hippocampal volume in elderly people with normal cognitive function

 

Hemoglobin A1c levels, %

p for trend

q value of FDR correction

<5.7 (n = 3406)

5.7–6.4 (n = 2989)

≥6.5 (n = 795)

Whole hippocampus, HV, mm3

6187.727 (6144.512–6230.942)

6193.960 (6149.737–6238.183)

6122.181 (6067.664–6176.698)

0.003*

–

Hippocampal subregions

 HATA, HV, mm3

97.152 (95.889–98.416)

96.858 (95.565–98.152)

95.597 (94.003–97.191)

0.046*

0.069

 Fimbria, HV, mm3

102.353 (99.642–105.064)

99.652 (96.878–102.427)

93.592 (90.172–97.012)

<0.001*

<0.001†

 Hippocampal fissure, HV, mm3

346.103 (342.022–350.184)

348.721 (344.545–352.898)

350.870 (345.721–356.019)

0.025*

0.060

 Molecular_layer, HV, mm3

803.394 (796.486–810.303)

805.025 (797.955–812.094)

796.674 (787.959–805.389)

0.049*

0.065

 GC ML DG, HV, mm3

540.797 (536.343–545.251)

540.954 (536.396–545.511)

535.250 (529.632–540.869)

0.026*

0.052

 CA1, HV, mm3

1211.672 (1201.436–1221.908)

1213.804 (1203.328–1224.279)

1203.977 (1191.063–1216.890)

0.150

0.180

 CA3, HV, mm3

397.392 (393.178–401.607)

399.835 (395.523–404.148)

395.177 (389.860–400.494)

0.038*

0.065

 CA4, HV, mm3

478.310 (474.420–482.201)

479.303 (475.322–483.284)

475.788 (470.880–480.696)

0.180

0.196

 Subiculum, HV, mm3

838.303 (831.211–845.395)

836.156 (828.898–843.413)

824.620 (815.673–833.567)

<0.001*

0.002†

 Presubiculum, HV, mm3

560.557 (554.904–566.210)

557.340 (551.555–563.125)

550.431 (543.300–557.562)

0.001*

0.004†

 Parasubiculum, HV, mm3

109.487 (107.416–111.557)

108.293 (106.174–110.412)

108.706 (106.094–111.318)

0.180

0.196

 Hippocampal tail, HV, mm3

1048.310 (1037.476–1059.144)

1056.740 (1045.653–1067.827)

1042.368 (1028.701–1056.036)

0.006*

0.018†

  1. CA Cornu Ammonis, eTIV estimated intracranial volume, FDR false discovery rate, GC ML DG granule cell and molecular cell layer of the dentate gyrus, HATA hippocampus amygdala transition area, HV hippocampal volume. Values are shown as multivariable-adjusted mean values (95% confidence intervals) where values are calculated as follows: (left + right) volumes of hippocampus or hippocampal subregions. Adjusted for age, sex, educational level, research site, apolipoprotein E Ɛ4, body mass index, hypertension, serum low-density lipoprotein cholesterol, serum high-density lipoprotein cholesterol, current smoking habits, current alcohol intakes, regular exercise, eTIV. *p for trend <0.05. †q value of FDR correction <0.05.
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