Fig. 9: Common and species-specific patterns of transcriptional gene regulation. | npj Aging

Fig. 9: Common and species-specific patterns of transcriptional gene regulation.

From: Adaptation of the Spalax galili transcriptome to hypoxia may underlie the complex phenotype featuring longevity and cancer resistance

Fig. 9

A Often, similar biological pathways are significantly enriched and activated (plus symbol) in the organs of both, Spalax and rat after hypoxic stress. B A complex picture emerges when differentially expressed genes within pathways are inspected: expression of different genes in Spalax and rat may lead to activation of the same pathway, as exemplified by Epas1 and Mdm2 (red = upregulation). In contrast, the same gene (here: Mknk1) can be regulated in opposite directions in response to hypoxia in the two species (blue = downregulation).

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