Fig. 3: IgG N-glycome changes in CALERIE2 participants.

A A representative CGE-LIF electropherogram of IgG N-glycome, with graphic representation of glycan structures corresponding to each glycan peak (P). B–E show the percentage change from baseline in the IgG glycome among a subset of CALERIE2 study participants (n = 26). Data were evaluated by mixed models using visit month as a repeated measure, participant as a random effect, baseline values for each parameter, sex, and age as covariates, followed by FDR correction. If the FDR corrected p-values were significant, multiple comparison tests (Tukey’s) were conducted. Significant p-values (inset in red) were obtained from Tukey’s tests.